A client who is complaining of tinnitus is describing a symptom that is: *

Tinnitus is an abnormal perception of sound which is reported by patients and unrelated to an external source of sound stimulation. Tinnitus is a very common disorder.

It may be intermittent, constant, or fluctuant, mild or severe, and may vary from a low roaring sensation to a high pitched type of sound. It may or may not be associated with a hearing loss. It is also classified further into subjective tinnitus (a noise perceived by the patient alone) or objective tinnitus (a noise perceived by the patient as well as by another listener). Subjective tinnitus is very common, while objective tinnitus is relatively uncommon. The site of tinnitus may be localized to one or both ears, or described as occurring in the head.

Symptoms

Tinnitus is a symptom much like a headache, pain, or vertigo. With tinnitus, the reported distress is usually subjective and difficult to record and appreciate by others. Some people are minimally affected by the tinnitus and only seem to notice the noise when in a quiet situation. On the other extreme, some can be very disturbed by the perceived noise, describing variable alteration in sleep patterns, poor concentrating abilities, and overall affects on their quality of life, with associated anxiety and distress.

The quality of tinnitus refers to the description by the patient of the tinnitus: it may be a ringing, buzzing, cricket, ocean, musical noise, etc., type sound. The quality may be multiple sounds or a singular sound.

Tinnitus may be produced in one or more locations, referred to as its site of lesion. The cause of tinnitus may be singular or multiple. A peripheral site of lesion (i.e. auditory nerve or cochlea) refers to dysfunction produced within the auditory system anywhere that extends from the ear up to, but not involving, the brainstem. A central site of lesion refers to involvement of the central auditory pathways, beginning at the brainstem and involving other portions of the central nervous system (brain).

Tinnitus is a symptom of neurotologic disease. It may occur with other symptoms of the ear including hearing loss, vertigo, and feelings of ear pressure, or it may occur alone. Patients are often surprised to learn that hearing loss greatly increases one’s chances of experiencing tinnitus. In fact, many times the cause of the tinnitus is attributable to the hearing loss itself. A person’s mood can change the quality or level of disturbance caused by the tinnitus. We find that tinnitus can increase when a person is anxious or under increased levels of stress.

A neurotologic examination and complete inner ear and auditory pathway evaluation is necessary in all patients complaining of tinnitus. The test battery is used to attempt to establish the site of lesion and to rule out any significant pathology, which may require further treatment. There are many causes of tinnitus related directly to the ear, such as simple ear wax. Middle ear abnormalities can also be responsible, including otosclerosis (fixation of the stapes bone in the middle ear), ear infections, and fluid in the middle ear. Inner ear causes include Meniere’s disease, exposure to excessively loud sounds, or sensorineural hearing loss. Tumors of the hearing nerve or middle ear, or other problems in the brainstem or central nervous system, may also cause tinnitus. Finally, vascular abnormalities in the neck, ear, or base of the skull may result in tinnitus.

Measurement

Since tinnitus often has a high pitch, frequency judgments in this region normally are poor. Frequency discrimination up to approximately 16,000 Hz (which is the upper limit of hearing) is far less exacting than the middle frequency region. In addition, patients suffering from high-pitched tinnitus often have a high frequency hearing loss, which may impair their frequency discrimination. Therefore, test-retest reliability in matching the frequencies of audiometer tones to the pitch of tinnitus may be poor. An attempt may be made, however, to do pitch matching and loudness-matching. In addition, an attempt may be made to determine the maskability of the tinnitus and to measure residual inhibition (i.e., the period of time that tinnitus remains temporarily reduced after a masking sound has been turned off).

bDeptartment of Neurology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea.

Find articles by Ho Won Lee

Tae You Kim

cWillis Hospital, Willis Medical Network, Busan, Korea.

Find articles by Tae You Kim

Jun Seong Lim

dDepartment of Neurology, Sung Ae Hospital, Seoul, Korea.

Find articles by Jun Seong Lim

Kyoung Sik Shin

eJeil Neurology Clinic, Willis Medical Network, Daejeon, Korea.

Find articles by Kyoung Sik Shin

Author information Article notes Copyright and License information Disclaimer

aDo Neurology Clinic, Willis Medical Network, Daegu, Korea.

bDeptartment of Neurology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea.

cWillis Hospital, Willis Medical Network, Busan, Korea.

dDepartment of Neurology, Sung Ae Hospital, Seoul, Korea.

eJeil Neurology Clinic, Willis Medical Network, Daejeon, Korea.

A client who is complaining of tinnitus is describing a symptom that is: *
Corresponding author.

Correspondence: Byung In Han, MD. Do Neurology Clinic, Willis Medical Network, 637 Jungang-dearo, Jung-gu, Daegu 700-440, Korea. Tel +82-53-252-2225, Fax +82-53-289-6502, ten.liamnah@nignuyb-nah

Received 2008 Nov 28; Revised 2009 Feb 13; Accepted 2009 Feb 13.

Copyright © 2009 Korean Neurological Association

Abstract

Tinnitus-the perception of sound in the absence of an actual external sound-represents a symptom of an underlying condition rather than a single disease. Several theories have been proposed to explain the mechanisms underlying tinnitus. Tinnitus generators are theoretically located in the auditory pathway, and such generators and various mechanisms occurring in the peripheral auditory system have been explained in terms of spontaneous otoacoustic emissions, edge theory, and discordant theory. Those present in the central auditory system have been explained in terms of the dorsal cochlear nucleus, the auditory plasticity theory, the crosstalk theory, the somatosensory system, and the limbic and autonomic nervous systems. Treatments for tinnitus include pharmacotherapy, cognitive and behavioral therapy, sound therapy, music therapy, tinnitus retraining therapy, massage and stretching, and electrical suppression. This paper reviews the characteristics, causes, mechanisms, and treatments of tinnitus.

Keywords: tinnitus, discordant theory, tinnitus retraining therapy

Introduction

Tinnitus is defined as a phantom auditory perception-it is a perception of sound without corresponding acoustic or mechanical correlates in the cochlea.1 Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life.2 A population-based study of hearing loss in adults aged 48 to 92 years found that tinnitus had a prevalence of 8.2% at baseline and an incidence of 5.7% during a 5-year follow-up.3 The prevalence of tinnitus increases with age.4

Tinnitus also represents a common symptom among children with hearing loss.5 Tinnitus is a subjective phenomenon that is difficult to evaluate objectively, with it being measured, quantified, and described only based on the responses of patients. Although tinnitus can have many different causes, it most commonly results from otologic disorders, with the most common cause believed to be noise-induced hearing loss.6 The various therapeutic approaches to tinnitus have produced mixed results, and hence it is generally assumed that tinnitus has diverse physiological causes.7

Clinical Manifestations

Characteristics of tinnitus

The sound perceived by those with tinnitus can range from a quiet background noise to a noise that is audible over loud external sounds. Tinnitus is generally divided into two categories: objective and subjective. Objective tinnitus is defined as tinnitus that is audible to another person as a sound emanating from the ear canal, whereas subjective tinnitus is audible only to the patient and is usually considered to be devoid of an acoustic etiology and associated movements in the cochlear partition or cochlear fluids. Many physicians use the term tinnitus to designate subjective tinnitus and the term somatosound to designate objective tinnitus.6

The sounds associated with most cases of tinnitus have been described as being analogous to cicadas, crickets, winds, falling tap water, grinding steel, escaping steam, fluorescent lights, running engines, and so on. It is believed that these types of perception result from abnormal neuronal activity at a subcortical level of the auditory pathway.6,8

The pattern characterizing tinnitus is related to the library of patterns stored in auditory memory and also, via the limbic system, associated with emotional states.9 The characteristics of tinnitus are generally unrelated to the type or severity of any associated hearing impairment, and thus the latter offers little diagnostic value.6 Most tinnitus patients match their tinnitus to a pitch above 3 kHz.10 The tinnitus characterizing Meniere's disease, described as roaring, matches a low-frequency tone that is usually from 125 to 250 Hz.11 However, tinnitus in the advanced "burned-out" stage of Meniere's disease is often higher in pitch and tonal in quality.12

Most patients with both tinnitus and hearing loss report that the frequency of the tinnitus correlates with the severity and frequency characteristics of their hearing loss, and that the intensity of the tinnitus is usually less than 10 dB above the patient's hearing threshold at that frequency.6 Some patients who have central auditory processing disorders and have difficulties understanding speech in noise report experiencing tinnitus even though their pure-tone audiometric thresholds are normal.8,13

Less prevalent forms of tinnitus, such as those involving well-known musical tunes or voices without understandable speech, occur among older people with hearing loss and are believed to represent a central type of tinnitus involving reverberatory activity within neural loops at a high level of processing in the auditory cortex.8,14

Somatic tinnitus is a type of subjective tinnitus in which the frequency or intensity is altered by body movements such as clenching the jaw, turning the eyes, or applying pressure to the head and neck.15 Reports that tinnitus is louder upon awakening suggest the involvement of somatic factors, such as bruxism. Reports that tinnitus vanishes during sleep but returns within a few hours further suggest that psychosomatic factors, such as neck muscle contractions occurring in an upright position or jaw clenching, play etiological roles.16

Because objective tinnitus (which is audible to another person) represents the semantic opposite of subjective tinnitus, a better nosological approach might be to use the term somatosound instead of objective tinnitus irrespective of whether the sounds are audible to others, reserving the term tinnitus for the perception of sound in the absence of any acoustic source. Thus, "tinnitus" would describe cases previously diagnosed as subjective tinnitus.6 Objective tinnitus might be vascular or mechanical in origin. Objective tinnitus of vascular origin could be a referred bruit from stenosis in the carotid or vertebrobasilar system. Objective mechanical tinnitus is due to abnormal muscular contraction of the nasopharynx or middle ear, as can occur in palatal myoclonus.17 Pulsatile tinnitus can also manifest subjectively as an increased awareness of blood flow in the ear. Indeed, the cause of somatosensory pulsatile tinnitus syndrome is not vascular, with the syndrome deriving from cardiac-synchronous somatosensory activation of the central auditory pathway or the failure of somatosensory-auditory central nervous system (CNS) interactions to suppress cardiac somatosounds.18 Pulsatile tinnitus superimposed on steady tinnitus could result from the pulsation of blow flow with the spiral capillary of the basilar membrane.19

Associated symptoms

The most common associated symptoms or subjective discomforts involve concentration difficulties, insomnia, and decreased speech discrimination.20 The annoyance of tinnitus is not correlated with the acoustic characteristics, but there is a significant correlation with psychological symptoms.21 The difference between simply perceiving tinnitus and being annoyed or distressed by it depends exclusively on the activation of the limbic and autonomic nervous systems.8 Most patients with significant tinnitus have difficulty falling asleep due to the accompanying anxiety, which also causes difficulties in returning to sleep during periods of wakefulness during the night.8

There is pronounced neuronal activity in the auditory pathways during sleep due to the auditory system continuously monitoring the sound environment.8 Common detrimental activities and/or conditions include noise exposure, being located in a quiet place, emotional stress, loss of sleep, and physical exhaustion.22 Annoyance, depression, and interference with sleep are more common and the tinnitus is louder in patients with Meniere's disease than in those with tinnitus deriving from other etiologies.22 Furthermore, the successful control of vertigo in patients with Meniere's disease can lead to them focusing more on their tinnitus and hence becoming more distressed by this condition.12

The strength of the reaction to tinnitus is therefore determined by its significance and by past experience-the actual intensity and characteristics of the sound are of secondary importance.23

Natural course

Noise-induced tinnitus can be acute or chronic. Acute tinnitus can last from a few minutes to a few weeks after noise exposure.24 In some cases, tinnitus has a gradual onset and several years can pass before an intermittent, low-intensity tinnitus becomes bothersome.25 Spontaneous remission by natural habituation is experienced by more than three-quarters of sufferers. Habituation occurs within the CNS, whereas adaptation involves a peripheral sensory organ.8 For those in whom the condition worsens, the tinnitus intensity increases over time but its pitch tends to remain stable.22 If tinnitus persists for more than 2 years, it is considered permanent and irreversible.26 However, chronicity is not associated with a favorable response to treatment.27

Causes and Pathophysiology

Causes

Tinnitus does not represent a disease itself but instead is a symptom of a variety of underlying diseases. Otologic causes include noise-induced hearing loss, presbycusis, otosclerosis, otitis, impacted cerumen, sudden deafness, Meniere's disease, and other causes of hearing loss. Neurologic causes include head injury, whiplash, multiple sclerosis, vestibular schwannoma (commonly called an acoustic neuroma), and other cerebellopontine-angle tumors. Infectious causes include otitis media and sequelae of Lyme disease, meningitis, syphilis, and other infectious or inflammatory processes that affect hearing. Tinnitus is also a side effect of some oral medications, such as salicylates, nonsteroidal anti-inflammatory drugs, aminoglycoside antibiotics, loop diuretics, and chemotherapy agents (e.g., platins and vincristine). Temporomandibular-joint dysfunction and other dental disorders can also cause tinnitus. However, in many cases no underlying physical cause is identifiable.28 For many years, hearing loss has been understood to be the most common cause of tinnitus,29 and population-based data indicate that excessive noise exposure represents the second most common cause of tinnitus. However, about 40% of patients cannot identify any cause associated with tinnitus onset.26

Any pathologic lesion in the auditory pathway or any reduction in auditory nerve function has the potential to produce tinnitus.19 The location of the hearing problem (i.e., in the middle ear or in the inner ear) and the otologic disorder causing the hearing loss do not appear to influence the etiologic potential.6 Interestingly, most patients with tinnitus complain about a sensation of fullness or blockage in the middle ear, suggesting a problem with middle ear pressure or increased impedance of the ossicular chain.30

Unilateral high-frequency hearing loss combined with poor speech discrimination suggests the presence of a tumor, usually a vestibular schwannoma/acoustic neuroma or a meningioma.28 Bilateral subjective tinnitus requires assessment of hearing and can be associated with presbycusis, noise-induced hearing loss, endolymphatic hydrops, and a vascular labyrinthine lesion.21 However, most cases of unilateral tinnitus are not associated with life-threatening otologic disease.6

Trigger factors

Small temporary changes in the outer hair cells (OHCs) following noise exposure can trigger the emergence of tinnitus by increasing the gain of the central auditory system.8 In general, tinnitus represents a threshold phenomenon for which any one factor, such as chronic progressive hearing loss, is insufficient to elicit its emergence-two or more trigger factors (i.e., psychosocial stress, noise exposure, and somatic factors) can act synergistically to produce symptomatic tinnitus.15 About 75% of new cases are related to emotional stress as the trigger factor rather than to precipitants involving cochlear lesions.8

Pathophysiology

Tinnitus represents a symptom of diverse pathologies. It is proposed that all levels of the nervous system are, to varying degrees, involved in tinnitus manifestation.1,31

Peripheral auditory system

Spontaneous otoacoustic emissions

Spontaneous otoacoustic emissions (SOAEs), first discovered by Kemp,32 are small acoustic signals presumed to be generated by the electromotile activity of the OHCs of the cochlea and propagated into the external auditory canal.33 SOAEs produced by the cochlea can be perceived as tinnitus.34 SOAEs are usually inaudible, but they can become audible due to instability.35 These atypical SOAEs are much more prevalent in the higher frequency range and can appear at sound pressure levels up to 55 dB SPL in the ear canal.36 Tinnitus due to SOAEs is mild and is more common in subjects with normal hearing and in those with only middle ear disorders.37 SOAEs decrease as hearing loss progresses, and hence these otoacoustic emissions are not likely to cause tinnitus when a hearing loss of 35 dB or more is present.38 However, SOAEs cannot fully explain the mechanism of tinnitus since aspirin largely abolishes SOAEs without improving tinnitus.39

Edge theory

Edge theory, also known as contrast theory, proposes that tinnitus is induced by increased spontaneous activity in the edge area,40 which represents a transition from OHCs in the organ of Corti with relatively normal morphology and function on the apical (i.e., low-frequency) side of a lesion to OHCs toward the basal side that are missing or have a pathologic appearance and poor functionality.19 Edge theory can be explained by discordant theory.9

Discordant theory

According to discordant theory, tinnitus is induced by the discordant dysfunction of damaged OHCs and intact inner hair cells (IHCs) of the organ of Corti. Intense noise and ototoxic agents initially damage OHCs in the basal turn of the cochlea, and subsequently, if continued or repeated, affect IHCsthis is due to IHCs being more resistant to such damage.9 IHCs are the receptor cells for sound transduction, and almost all afferent fibers in the auditory nerve (95%) innervate IHCs.8 In contrast, OHCs work as mechanical amplifiers, enhancing weak sounds by providing up to 50 dB, which can be evaluated by measuring otoacoustic emissions.8 In almost all situations OHCs are damaged more than IHCs, which results in the disinhibition of neurons in the dorsal cochlear nuclei (DCNs).8 Spontaneous activity is increased when neurons in the DCN receive excitation from IHCs but not from the damaged OHCs, and this is perceived as tinnitus.8 Normally there is a small gap between the top of the cilia of the IHCs and the bottom of the tectorial membrane, but in the area in which OHCs are affected but IHCs are intact, the tectorial membrane might touch the IHC cilia, thus causing the IHCs to depolarize.41 The OHCs normally recover with a few days, but this can be delayed for up to a few months.42,43 Therefore, it is hypothesized that tinnitus represents a consequence of a central gain adaptation mechanism when the auditory system is confronted with a hearing loss.44 Discordant theory explains why many individuals with tinnitus have normal hearing if there is only partial damage to OHCs, since up to 30% of OHCs can be damaged without inducing hearing loss.45 OHCs die at a rate of approximately 0.5% per year beginning during the first years of life, and OHC-induced hearing loss does not usually appear before the end of the fifth decade of life.8 Discordance is absent in totally deaf individuals with complete damage to both OHCs and IHCs, and hence tinnitus is not induced. If there is increased gain within the CNS, tinnitus is present even in deaf subjects.23 Similarly, noise-induced tinnitus is caused by discordant damage between OHCs and IHCs.41 Two types of noise-induced tinnitus have been identified: tonal and complex. Tonal tinnitus results from discordant dysfunction of OHCs and IHCs manifesting in a single area, whereas complex tinnitus results from multiple areas of discordance.46 When patients clearly have the central type of tinnitus, such as after transection of the auditory nerve, the OHC concept is not applicable and alternative mechanisms need to be considered.23

Central auditory system

The dorsal cochlear nucleus

The DCN has been implicated as a possible site for the generation of tinnitus-related signals owing to its tendency to become hyperactive following exposure to tinnitus-inducing agents such as intense sound and cisplatin.47 OHC damage triggers plastic readjustments in the DCN, resulting in DCN hyperactivity.48 It is hypothesized that a reduction in auditorynerve input leads to disinhibition of the DCN and an increase in spontaneous activity in the central auditory system, which manifests as tinnitus.49 This mechanism could explain the temporary ringing sensation that can follow exposure to loud sound.50 The plastic readjustments in the DCN are slow and lead to tinnitus with a delayed onset. IHC damage prevents hyperactivity in the DCN.51

Auditory plasticity theory

According to auditory plasticity theory, damage to the cochlea enhances neural activity in the central auditory pathway.52 Auditory plasticity emerges as a consequence of the aberrant pathway, and tinnitus might be considered to be the auditory system analog to phantom limb sensations in amputees.53 Tinnitus might be generated in the temporal lobe in the auditory association cortex54 and inferior colliculus.55 The ability of some individuals to modulate tinnitus by performing voluntary somatosensory or motor actions is probably attributable to plastic changes involving the development of aberrant connections between the auditory and sensory-motor systems in the brains of these patients.56

Crosstalk theory

According to crosstalk theory, when auditory nerve fibers are intact and some other cranial nerves are damaged, artificial synapses (called crosstalk) can develop between individual auditory nerve fibers, resulting in the phase-locking of the spontaneous activity of groups of auditory neurons. In the absence of external sounds, this creates a neural pattern that resembles patterns evoked by actual sounds.57 These cranial nerves are sensitive to compression at the root entry zone, where they are covered by myelin. Nerve compression causes crosstalk between nerve fibers, and the breakdown of the myelin insulation of the nerve fibers establishes ephaptic coupling between them. This notion is applied to the cochlear-vestibular nerve, which is covered by central myelin for most of its length and hence is vulnerable to compression from blood vessels or tumors impinging upon the nerve (e.g., vestibular schwannoma). Such compression and consequent ephaptic coupling might lead to tinnitus if synchronization of the stochastic firing in the cochlear nerve is perceived as sound.57

Somatosensory system

The activity of the DCN is also influenced by stimulation of nonauditory structures;47 however, the somatosensory system is the only nonauditory sensory system that appears to be related to tinnitus (e.g., in temporomandibular-joint syndrome and whiplash).49 Somatic tinnitus can develop from activation of latent oto-somatic interaction.16 Somatic (craniocervical) tinnitus, like otic tinnitus, is caused by disinhibition of the ipsilateral DCN, which is mediated by nerve fibers whose cell bodies lie in the ipsilateral medullary somatosensory nuclei. These neurons receive inputs from the nearby spinal trigeminal tract, the fasciculus cuneatus, and the facial, vagal, and glossopharyngeal nerve fibers innervating the middle and external ears.49

Pain signals from the cochlea carried by the cochlear C fibers could also be interpreted by the CNS as tinnitus.58 It is further hypothesized that somatic tinnitus is due to central crosstalk within the brain, because certain head and neck nerves enter the brain near regions known to be involved in hearing.57

Limbic and autonomic nervous systems

The aforementioned theories cannot explain why some people suffer from tinnitus while others do not. More than 80% of those perceiving tinnitus for the first time do not associate the sound with any negative meaning and experience spontaneous habituation. However, if the first perception of tinnitus induces high levels of annoyance or anxiety by association with unpleasant stimuli or with periods of stress and anxiety, tinnitus mightlead to high levels of annoyance or anxiety. At the unconscious level, tinnitus can increase progressively without the patient being aware, resulting in enhanced activity in the limbic and autonomic nervous systems. In such situations, tinnitus emerges as a clinically significant problem.8

Treatments

Tinnitus treatments can be divided into two categories: 1) those aimed at directly reducing the intensity of tinnitus and 2) those aimed at relieving the annoyance associated with tinnitus. The former include pharmacotherapy and electrical suppression,59 and the latter include pharmacotherapy, cognitive and behavioral therapy, sound therapy, habituation therapy,60 massage and stretching, and hearing aids.

Pharmacotherapy

Extensive reviews of randomized clinical trials have revealed that only nortriptyline, amitriptyline, alprazolam, clonazepam, and oxazepam are more beneficial than placebo.59,61 Dobie et al. reported that nortriptyline were statistically superior to placebo, although placebo was also effective.62 Podoshin et al. reported that amitriptyline was superior to placebo with respect to sleep disturbance and interference with activities.63 Johnson et al. reported that alprazolam was more effective than placebo in reducing tinnitus intensity.64 Lechtenberg and Shulman noted that clonazepam and oxazepam were effective in more than 50% of tinnitus cases.65 However, when patients stopped taking either of these drugs, tinnitus recurred to its prior level or a worse level.65 The only medication providing a reliable reduction of tinnitus is intravenous lidocaine, and there is a close association between the effects of lidocaine and oral carbamazepine.66 Intravenous lidocaine produces a change in the neural activity in the right temporal lobe in the auditory association cortex.54 Unfortunately, lidocaine cannot be used clinically because it must be injected, its effects are of short duration, and it frequently produces adverse side effects.61 Tocainide, an oral antiarrhythmic drug closely related to lidocaine, is not beneficial.67 Tinnitus due to SOAEs can be diminished by aspirin.68 A recent 3-month randomized clinical trial involving 50 patients found that acamprosate, a drug used in the treatment of alcoholism, was more beneficial than placebo.69 Flecainide, mexiletine, betahistine, carbamazepine, ginko extract, amylobarbiturate, baclofen, lamotrigine, misoprostol, zinc, cinnarizine, flunarizine, caroverine, eperisone, and melatonin are no more beneficial than placebo.59 Diazepam and flurazepam significantly change the tinnitus intensity.61

Cognitive and behavioral therapy

Cognitive therapy focuses on how one thinks about tinnitus and on the avoidance of negative ideation, whereas behavioral therapy uses the systematic desensitization approach that is applied to many phobias.70 Cognitive therapy involves teaching patients to cope with their tinnitus by replacing negative thinking with more positive thinking. Cognitive therapy includes counseling and cognitive restructuring. Counseling should include 1) informing patients that it is unlikely that their annoyance with tinnitus will improve dramatically, 2) informing patients about the usefulness of tinnitus self-help groups, 3) helping patients to minimize the time devoted to activities and/or conditions in which the tinnitus intensity is increased and to maximize the time devoted to activities and/or conditions in which the tinnitus intensity is decreased, and 4) stressing the avoidance of noise exposure, since noise-induced hearing loss and tinnitus are related.22 Cognitive restructuring involves changing thoughts associated with tinnitus. In this context, patients are encouraged to accept the idea that tinnitus does not deserve all the attention it gets.71 Behavioral therapy focuses on positive imagery, attention control, and relaxation training.70 Positive imagery involves focusing thoughts on something pleasant, thereby diverting thoughts from tinnitus. Patients begin with pleasant visual images (e.g., lying on a beach) and auditory images (e.g., the sound of waves or wind through the leaves).70 Attention control involves moving attention away from the tinnitus when it is bothersome. This process might begin by placing two pictures next to one another and then presenting two acoustic stimuli (e.g., a fan noise and conversational speech) emanating from an adjacent room. Next, a picture and the tinnitus are paired, followed by the pairing of a thought and the tinnitus.70 Relaxation training uses a guided protocol to teach participants to apply progressive muscle relaxation, involving tensing and relaxing the arms, face, neck, shoulders, abdomen, legs, and feet.70

Sound therapy

Sound therapy uses sounds found in natural settings, including those associated with streams, rain, waterfalls, and wind, to decrease the strength of the tinnitus-related neuronal activity within the auditory system.72 To this end, the background neuronal activity in the auditory system is increased by exposing the patient to a low-level, continuous, neutral sound23 that is nonintrusive, not annoying, and easy to ignore. Such a sound should not be meaningful, pleasant, or arousing in a way that attracts attention, making listening to a television, the radio, or music unsuitable.8 Neutral sounds should be stable and not overwhelming; therefore, the sounds of waves are not recommended.23 Some patients are distracted by the sounds of bird calls, crickets, or thunderstorms, and hence care is required when applying these sounds.72 Sound therapy can employ various sound sources, such as table-top sound machines and compact disc players. The sound intensity should be at or below the level at which the patient can perceive the tinnitus and the external sound separately.23 The sound must be applied bilaterally to avoid asymmetrical stimulation of the auditory system, since stimulating only one side in unilateral tinnitus frequently results in a shift of the perceived location of the tinnitus to the opposite side due to strong interactions within the auditory pathways. Occlusion with ear plugs should be minimized by using open-ear molds to allow normal access of environmental sounds to the ear.8 Applying sound therapy during the night can be helpful for individuals without sleep problems because the auditory pathways are fully active up to the level of the inferior colliculi during sleep.23 Based on a report that the continuous sound exposure increases blood flow to the inner ear of rat,73 sound therapy might affect the physiology of human cochlea.

Hearing aids

Hearing aids represent another form of sound therapy that is usually beneficial to tinnitus patients with significant hearing loss.72 Hearing aids are designed to improve the audibility of speech and to amplify ambient sounds. Amplification of speech diverts attention away from tinnitus, and amplification of other ambient sounds serves to partially mask tinnitus. Hearing aids are not appropriate for those with hearing loss confined to above 6 kHz, because most hearing aids have limited high-frequency amplification abilities.74 The use of hearing aids can permanently reduce the neural activity responsible for tinnitus generation and perception,72 and usually represents the first intervention for patients with hearing impairment.74 Many hearing-impaired patients have normal or near-normal hearing at low frequencies, and common environmental sounds contain a significant amount of energy below 200 Hz, which provides constant sound stimulation and thus helps to prevent difficulties associated with increased gain in the auditory system. Therefore, it is crucial to fit hearing aids with open molds in the external ear to avoid blocking these low frequencies.8

Music therapy

Music therapy is a desensitization method that utilizes music that has been spectrally modified according to the hearing characteristics of each patient to allow the masking of tinnitus and to facilitate relaxation at a comfortable listening level.75 Music directly affects the limbic system, bypassing the slower linguistically based processing in the auditory cortex.75 Hearing thresholds decline substantially above 3 kHz among many tinnitus patients, and hence the spectral modification should involve reducing the energy of lower frequency components of the music.75

Tinnitus retraining therapy

Tinnitus retraining therapy (TRT) is a form of habituation therapy designed to help tinnitus sufferers. TRT mainly targets nonauditory systems, particularly the limbic and autonomic nervous systems, and is based on the assumption that tinnitus represents a side effect of the normal compensatory mechanisms in the brain. TRT uses naturally occurring mechanisms of plasticity in the brain to achieve habituation to the physiological reactions to tinnitus and, subsequently, to achieve habituation to the very perception of tinnitus.8 Habituation is typically achieved by repeating the sensory stimulus. However, this method cannot be directly applied to tinnitus because it is impossible to eliminate the reactions of the autonomic nervous system that act as a negative reinforcement. Therefore, TRT involves decreasing both the stimulus and the reinforcement, even though these remain present.8

TRT consists of two components: retraining counseling and sound therapy. Retraining counseling aims to help patients to think of their tinnitus as a type of neutral sound.8 Neutralizing tinnitus is achieved by showing the patient that tinnitus is not associated with threatening pathology.23 The creation of positive associations with tinnitus represents an additional way of neutralizing tinnitus. Descriptions such as screeching, tearing, and steam jets should be replaced by benign, more peaceful descriptions, such as "music of the brain".8 Sound therapy aims at facilitating habituation at an unconscious level by decreasing the strength of the signal. The addition of sound decreases the difference between tinnitus and background sounds.8 However, TRT requires about 18 months to achieve observable stable effects, and this time-consuming treatment does not achieve satisfactory results in some patients. TRT requires patience and discipline from both the patient and a knowledgeable and experienced professional.28

Massage and stretching

Massage and stretching of the neck and masticatory muscles have been associated with significant improvement in tinnitus.59 Patients with somatic tinnitus can have symptoms of cervical spine disorders, including head, neck, and shoulder pain as well as limitations in sideways bending and rotation. Treating jaw and neck disorders has beneficial effects on tinnitus. Injecting lidocaine into jaw muscles, such as the lateral pterygoid, also reduces tinnitus.76

Electrical suppression

Electrical stimulation of the cochlea with trains of pulses at 5,000 pulses per second can substantially or completely suppress tinnitus with either no perception or only a transient perception of the stimulus. Stimulus with electrical pulses at such a high rate restores spontaneous-like patterns of spike activity in the auditory nerve, which could explain how it suppresses tinnitus.77

Transcutaneous electrical nerve stimulation of areas of skin close to the ear increases the activation of the DCN via the somatosensory pathway and could augment the inhibitory role played by this nucleus on the CNS, thereby ameliorating tinnitus.78

CONCLUSION

Tinnitus frequently represents a symptom of an associated disease process. Recent research has employed state-of-the-art imaging and measurement technology to examine tinnitus-related activity in the ear, auditory nerve, and auditory tracts of the brain. These studies have increasingly focused on exploring putative brain-related mechanisms. The complexity of the changes in the nervous system associated with tinnitus might explain why this condition has proved so resistant to treatment.28 Although numerous therapeutic modalities have been applied, no consensus regarding effective therapeutic agents has emerged. At times, no treatment represents the better alternative, mandating that clinicians are able to placate patients without resorting to unnecessary prescriptions.28 Although treatment does not necessarily relieve tinnitus, accurate diagnosis and treatment are important for reduing the annoyance associated with tinnitus and for preventing additional disability. Furthermore, many randomized clinical trials have found strong placebo effects that have been partly attributed to responses to attention.

Nevertheless, counseling represents an essential part of treatment, regardless of the management approach adopted for a particular patient. An informed explanation of tinnitus, together with reassurance, improves the condition of most patients over time. For those with persistent tinnitus, cognitive and behavioral therapy, augmented by pharmacologic intervention, might represent the most promising treatment regimen. Most importantly, a strong doctor-patient relationship underpins successful management and high levels of satisfaction among patients.